Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:75213 Rosemann M, et al., Bone tumorigenesis induced by alpha-particle radiation: mapping of genetic Loci influencing predisposition in mice. Radiat Res. 2002 Apr;157(4):426-34
• ID
  MGI:3577296

Genes

Gene	Assay Type
Ossc1	resistance/susceptibility
D7Mit145	PCR amplified length variant
Xrcc1	reported elsewhere
Bax	reported elsewhere
Fosb	reported elsewhere

Notes

• Experiment
  47 female animals from a T Stock x (C3H/HeJ x 102/El)F1 population were treated with ²²⁷thorium at 100 days of age to induce osteosarcoma. 54 microsatellite markers were screened in these animals to identify QTLs associated with osteosarcoma susceptibility. Suggestive linkage was detected at 26 cM on mouse Chromosome 7 (LOD=1.37 at D7Mit145) and at 45 cM on mouse Chromsome 14 (LOD=105 at D14Mit219.)
  
  When both loci were analyzed together as interacting QTL the LOD score increased to 3.48. The chromosome 7 QTL is designated Ossc1 (osteosarcoma susceptibility 1) and the chromosome 14 QTL is designated Ossc2 (osteosarcoma susceptibility 2). The 102/El-derived allele confers resistance to osteosarcomas at Ossc1 but confers susceptibility at Ossc2. 75% of ²²⁷thorium-treated animals with susceptibility alleles at both Ossc1 (C3H/HeJ-derived) and Ossc2 (102/El-derived) develop osteosarcoma. Potential candidate genes for Ossc1 are Bax (23 cM), Xrcc1 (5.5 cM), and Fosb (5 cM). A potential candidate gene for Ossc2 is Rb1 (41 cM).