Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:40728 Krulova M, et al., IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations. Genomics. 1997 May 15;42(1):11-5
• ID
  MGI:3529485

Genes

Gene	Assay Type
Cinda1	visible phenotype
D11Mit4	PCR amplified length variant
Itk	reported elsewhere
Il4	reported elsewhere
Il5	reported elsewhere
Csf2	reported elsewhere
Il13	reported elsewhere
Irf1	reported elsewhere
Ccl11	reported elsewhere
Ccl7	reported elsewhere
Nos2	reported elsewhere
Ccl1	reported elsewhere
Ccl2	reported elsewhere
Ccl3	reported elsewhere
Ccl4	reported elsewhere
Ccl6	reported elsewhere
Ccl9	reported elsewhere
Emv14	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 520 (CcS-4/Dem x BALB/c)F2 animals to identify QTLs associated with T lymphocyte proliferation in response to IL-2 stimulation. Parental strain CcS-4/Dem is a high responder and parental strain BALB/c is a low responder.CcS-4/Dem is a recombinant congenic strain carrying STS/A-derived donor DNA segments on a BALB/c genetic background. CcS-4/Dem differs from BALB/c at DNA segments on 8 different chromosomes. 23 microsatellite markers covering the differential region were typed in the F2 animals.
  
  Cinda1 maps to mouse Chromosome 11 near D11Mit4 (37 cM). This locus is linked to T lymphocyte proliferation in response to high levels of IL-2. The BALB/c-derived allele confers increased T lymphocyte proliferation at Cinda1. Potential candidate genes mapping near Cinda1 are Itk (22 cM), Il4 (29 cM), Il5 (29.2 cM), Csf2 (29.5 cM), Il13 (29 cM), Irf1 (29 cM), Ccl11 (47 cM), Ccl7 (46.5 cM), Nos2 (45.6 cM), Ccl1 (47.3 cM), Ccl2 (46.5 cM), Ccl3 (47.6 cM), Ccl4 (47.6 cM), Ccl6 (47.5 cM), Ccl9 (47.4 cM), and Emv14 (37 cM). A previously identified QTL named Tria1 (28 cM) also maps near Cinda1.
  
  Cinda2 maps to mouse Chromosome 12 near D12Mit37 (1 cM). This locus is linked to T lymphocyte proliferation in response to low levels of IL-2. The STS/A-derived allele confers increased T lymphocyte proliferation at Cinda2. Potential candidate genes mapping near Cinda2 are Xmmv39, Mtv30 (1 cM), and Pmv37 (3 cM).