Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:79991 Rozmahel R, et al., Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14452-7
• ID
  MGI:2684309

Genes

Gene	Assay Type
Mnotch
D1Mit150	PCR
Ncstn	assembly
Psen2	assembly

Notes

• Experiment
  Notch-mild C57BL/6J mice 129 F2-Psen -/- mice were informative in mapping a modifier of Notch to mouse Chromosome 1 with a LOD score of ~ 6.0 with D1Mit150. Nicastrin (9430068N19Rik) and Presenilin 2 also mapped to this region. The authors concludedthat PS2 ( Presenilin 2) is unlikely to be the modifier, whereas more analysis is required for Nicastrin.