Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:78551 Dohmoto A, et al., Quantitative trait loci on chromosomes 10 and 11 influencing mandible size of SMXA RI mouse strains. J Dent Res. 2002 Jul;81(7):501-4
• ID
  MGI:2663073

Genes

Gene	Assay Type
Mndl1	visible phenotype
D11Mit52	PCR amplified length variant
Hba	PCR amplified length variant
Otx1	reported elsewhere
Mndl2	visible phenotype
D11Mit229	PCR amplified length variant
D11Mit163	PCR amplified length variant

Notes

• Experiment
  400 polymorphic markers were screened in 21 SMXA (SM/J x A/J) recombinant inbred (RI) strains to identify QTLs associated with mandible size. Parental strain SM/J has a small mandible compared to parental strain A/J. Two significant QTLs, Mndl1 and Mndl2, mapped to 13 cM and 16 cM on mouse Chromosome 11, respectively. Mndl1 gives peak linkage between markers D11Mit152 and Hba with LOD>4.0. SM/J-derived alleles confer small mandible size at Mndl1 and a candidate gene mapping to the region is Otx1. Mndl2 gives peak linkage between markers D11Mit229 and D11Mit163 with LOD>4.0. A/J-derived alleles confer increased mandible size at Mndl2. A suggestive locus mapped to 60 cM on mouse Chromosome 10 with LOD>2.2 between D10Mit70 and D10Mit136. A/J-derived allelesare associated with small mandibles while SM/J-derived alleles are associated with large mandibles at this locus.