Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:73763 Grattan M, et al., Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci. Diabetes. 2002 Jan;51(1):215-23
• ID
  MGI:2182411

Genes

Gene	Assay Type
Idd4	visible phenotype
D11Nds1
D11Mit38
D11Mit325
Pafah1b1	reported elsewhere
Nos2	reported elsewhere
Ccl2	reported elsewhere
Ccl3	reported elsewhere
Ccl4	reported elsewhere

Notes

• Experiment
  Using novel congenic lines NOD.B6-Idd4/ADel, NOD.B6-Idd4/BDel, and NOD.B6-Idd4/CDel, the Idd4 locus was localized to a 5.2 cM interval on mouse Chromosome 11 and may possibly be comprised of 2 separate subloci, which the authors designate Idd4.1 and Idd4.2. Congenic line NOD.B6-Idd4/ADel carries a segment of C57BL/6J-derived DNA from D11Nds1 to D11Mit325 introgressed onto the genetic background of the diabetes type 1 susceptible NOD strain. (The C57BL/6J donor strain is diabetes type 1-resistant.) Congenic lines NOD.B6-Idd4/BDel and NOD.B6-Idd4/CDel carry C57BL6/J-derived DNA segments at D11Mit38-D11Mit325 and D11Mit38, respectively, on an NOD background. All congenic lines exhibit protection from diabetes type 1 as seen by the dramatic delay in disease onset compared to the NOD background strain (22 weeks vs 12-15 weeks). Upon examination of the congenic lines, the interval centered around D11Nds1 (Idd4.1) appears to be associated with reduced numbers of islet infiltrating cells, whereas the interval centered around D11Mit38 and D11Mit325 (Idd4.2) appears to be associated with T-cell proliferative response and delayed onset of disease. Potential candidate genes mapping to these intervals are Pafah1b1, Nos2, Ccl2, Scya3, and Scya4.