Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:60775 Wakana S, et al., Gene mapping of SEZ group genes and determination of pentylenetetrazol susceptible quantitative trait loci in the mouse chromosome. Brain Res. 2000 Feb 28;857(1-2):286-90
• ID
  MGI:2158373

Genes

Gene	Assay Type
Ptz1a	resistance/susceptibility
Ptz1b	resistance/susceptibility
D2Mit14a
D2Mit237
D2Mit458
D2Mit61
Cacnb2	reported elsewhere
Cacnb4	reported elsewhere
D2Mit521

Notes

• Experiment
  235 (C57BL/6J x DBA/2J)F2 animals and 26 BXD recombinant inbred strains were analyzed for microsatellite markers on the X chromosome to identify loci associated with pentylenetetrazol (PTZ) induced seizures. Parental strain C57BL/6J exhibits resistance to PTZ induced seizures whereas DBA/2J exhibits susceptibility. Two significant loci mapped to mouse Chromosome 2, Ptz1a and Ptz1b. Ptz1a spans 28 cM - 50 cM with a peak LOD score of 7.9 near D2Mit61 at approximately 34 cM. Cacnb4 maps near Ptz1a and may be a candidate gene. Ptz1b spans 10 cM - 26 cM with a peak LOD score of 3.2 near D2Mit521 at approximately 15 cM. Cacnb2 maps near Pzt1b and may be a candidate gene. Sequence comparison of regions encompassing Cacnb2 and Cacnb4 did not reveal differences between C57BL/6J and DBA/2J. A suggestive locus was detected on mouse Chromosome 7 which the authors name Ptz2.