Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:60445 Haywood ME, et al., Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice. Arthritis Rheum. 2000 Feb;43(2):349-55
• ID
  MGI:2149098

Genes

Gene	Assay Type
Sle7	visible phenotype
Sle8	visible phenotype
Sle9	visible phenotype
Sle10	visible phenotype
D1Mit5.1
D1Mit12
D1Mit403
D1Mit3
Bcl2	reported elsewhere
Ctla4	reported elsewhere
Cd28	reported elsewhere
Cfh	reported elsewhere
Fcgr2b	reported elsewhere
Fcgr3	reported elsewhere

Notes

• Experiment
  286 [C57BL/10Ola x C56BL/10Ola x BXSB/J)F1] male backcross animals were typed at 93 polymorphic loci (average spacing=20 cM) to identify QTLs involved in systemic lupus erythematosus (SLE) susceptibility. The BXSB/J strain develops accelerated autoimmunedisease in male animals with a phenotype similar to human SLE. C57BL/10Ola males are non-autoimmune and [C57BL/10Ola x C56BL/10Ola x BXSB/J)F1] backcross males develop autoimmune disease with delayed onset. Linkage was detected on mouse Chromosome 1 at 32.8 cM (Sle7), 71.4 cM (Sle8), and 99.5 cM (Sle9). Sle7 peaks at D1Mit5 and shows significant linkage to glomerulonephritis (GN) and suggestive linkage to antinuclear antibody (ANA) production and splenomegaly. Sle8 peaks at D1Mit12 and shows significant linkage to GN, ANA, and splenomegaly. Sle9 peaks at D1Mit403 and is linked to ANA, splenomegaly, anti-ssDNA antibody production, and anti-dsDNA antibody production. Suggestive loci were detected on mouse Chromosome 1 at 7.7 cM (Sle10) and mouse Chromosome 3 at 39.7 cM (Sle11). Sle10 is associated with lymphoadenopathy at D1Mit3, and Sle11 is associated with ANA and elevated IgG3 levels at D3Mit40. (See also Maibaum, J:61936)