Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:67544 Morel L, et al., The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1787-92
• ID
  MGI:1931845

Genes

Gene	Assay Type
Sle1	reported elsewhere
Sle1a	visible phenotype
Sle1b	visible phenotype
Sle1c	visible phenotype
D1Mit15	PCR amplified length variant
D1Mit353	PCR amplified length variant
D1Mit113	PCR amplified length variant
D1Mit407	PCR amplified length variant
D1Mit206	PCR amplified length variant
D1Mit274	PCR amplified length variant
D1Mit17	PCR amplified length variant

Notes

• Experiment
  Systemic lupus erythematosus (Sle) is measured via anti-chromatin IgG production. Fine mapping of loci around Sle1 indicate that Sle1 actually corresponds to a cluster of loci related in part to Sle1. Various mating paradigms were used to dissect the Sle1 interval, including 493 (NZM2410 X C57BL/6J) F1 meioses. In addition (B6.Sle1 X C57BL/6J) x C57BL/6J recombinants were intercrossed to create more recombinants and to develop sublines on a C57BL/6J background.
  
  Interestingly three non overlapping regions were identified within Sle1 designated as Sle1a, Sle1b and Sle1c. The following congenic intervals were identified.
  Sle1a is included in an interval bounded by D1Mit15 and D1Mit353.
  Sle1b is included in an interval bounded by D1Mit113 and D1Mit407 and by D1Mit113 and D1Mit206.
  Sle1c is included in an interval bounded by D1Mit274 and D1Mit17.