Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  10
• Reference
  J:66698 Di Palma F, et al., Mutations in cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for usher syndrome type 1D. Nat Genet. 2001 Jan;27(1):103-7
• ID
  MGI:1931468

Genes

Gene	Assay Type
Cdh23	overlapping clones, direct sequencing

Notes

• Experiment
  The authors mapped the waltzer mutation to a 0.35 cM region in a high-resolution genetic cross and established a 500kb BAC contig covering the critical interval. Sequence analysis for genes in the region revealed the presence of a gene designated as Cdh23. Analysis of three different alleles of waltzer showed mutations in Cdh23 that were predicted to lead to a loss of function.