Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  2
• Reference
  J:51944 Silver A, et al., Molecular mapping of chromosome 2 deletions in murine radiation-induced AML localizes a putative tumor suppressor gene to a 1.0 cM region homologous to human chromosome segment 11p11-12. Genes Chromosomes Cancer. 1999 Feb;24(2):95-104
• ID
  MGI:1342558

Genes

Gene	Assay Type
D2Mit332	overlapping clones, PCR amplified length variant
D2Mit94	overlapping clones, PCR amplified length variant
D2Mit75	overlapping clones, PCR amplified length variant
D2Mit248	overlapping clones, PCR amplified length variant
D2Mit436	overlapping clones, PCR amplified length variant
Ssrp1	overlapping clones, PCR amplified length variant
D2Mit160	overlapping clones, PCR amplified length variant
D2Mit66	overlapping clones, PCR amplified length variant
Ctnnd1	overlapping clones, PCR amplified length variant
D2Mit126	overlapping clones, PCR amplified length variant
D2Mit272	overlapping clones, PCR amplified length variant
Celf1	overlapping clones, PCR amplified length variant
Rapsn	overlapping clones, PCR amplified length variant
Spi1	overlapping clones, PCR amplified length variant
F2	overlapping clones, PCR amplified length variant
D2Mit43	overlapping clones, PCR amplified length variant
D2Mit385	overlapping clones, PCR amplified length variant
D2Mit42	overlapping clones, PCR amplified length variant
Tsp9	visible phenotype
D2Mit333	overlapping clones, PCR amplified length variant
D2Mit130	overlapping clones, PCR amplified length variant
D2Mit249	overlapping clones, PCR amplified length variant
D2Mit350	overlapping clones, PCR amplified length variant
D2Mit351	overlapping clones, PCR amplified length variant
D2Mit386	overlapping clones, PCR amplified length variant
D2Mit129	overlapping clones, PCR amplified length variant
D2Mit387	overlapping clones, PCR amplified length variant
D2Mit44	overlapping clones, PCR amplified length variant
D2Mit185	overlapping clones, PCR amplified length variant
D2Mit13	overlapping clones, PCR amplified length variant
D2Mit252	overlapping clones, PCR amplified length variant
D2Mit100	overlapping clones, PCR amplified length variant
D2Mit241	overlapping clones, PCR amplified length variant
D2Mit128	overlapping clones, PCR amplified length variant

Notes

• Experiment
  The authors used X-ray irradiated (C57BL-Lia x CBA/H)F1 mice as a model of murine myeloid leukemia. A majority of these mice contain Chromosome 2 aberrations. Since the breakpoints of the deletions are different, the authors propose the presence of tumorsuppresor genes in the deleted region rather than breakpoint induced lesions as the cause of the leukemic phenotype. Microsatellite mapping of the tumors was used to construct a physical map of the Tsp9 region. This region was narrowed to approximately a 1.0 cM interval between D2Mit126 and D2Mit185. The order of loci in this region of mouse Chromosome 2 is: D2Mit332 - D2Mit94 - D2Mit75 - D2Mit248 - D2Mit436 - Ssrp1 - D2Mit160 - D2Mit66 - Catns - D2Mit126 - D2Mit272 - Cugbp1 - Rapsn - (Sfpi1 - F2)- D2Mit43 - D2Mit385 - D2Mit42 - Tsp9 - D2Mit333 - D2Mit130 - D2Mit249 - D2Mit350 - D2Mit351 - D2Mit386 - D2Mit129 - D2Mit387 - D2Mit44 - D2Mit185 - D2Mit13 - D2Mit252 - D2Mit100 - D2Mit214 - D2Mit128.