Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  15
• Reference
  J:47640 Herbarth B, et al., Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5161-5
• ID
  MGI:1332317

Genes

Gene	Allele	Assay Type	Description
D15Mit68		reported elsewhere
Mb		reported elsewhere
Csf2rb		reported elsewhere
Csf2rb2		reported elsewhere
Sstr3		reported elsewhere
Il2rb		reported elsewhere
D15Mit1		reported elsewhere
D15Mit119		reported elsewhere
Lgals1		reported elsewhere
H1f0		SSCP	H1fv-pA, H1fv-pB
D15Mit71		reported elsewhere
Sox10	Sox10^Dom	PCR amplified length variant	Sox10-pA, Sox10-pB
Pdgfb		reported elsewhere
D15Mit2		reported elsewhere

Notes

• Experiment
  In order to refine the Dom critical region on mouse Chromosome 15 528 mice from a previously identified cross (J:29847, Puliti A; et al. A high-resolution genetic map of mouse Chromsome 15 encompassing the Dominant megacolon (Sox10^Dom) locus. Mamm Genome 1995 Nov; 6(11):763-768) indicated that Sox10^Dom was flanked by markers Il3rb1 and Pdgfb. The EUCIB mapping panel served as the framework to establish the genetic order of loci the Sox10^Dom region as follows: D15Mit68 - Mb - 0.33 cM - Il3rb1 - Il3rb2 - Sstr3 - Il2rb - 0.53 cM - D15Mit1 - 0.13 cM - D15Mit119 - Lgals1 - H1f0 - 0.22 cM - D15Mit71 - Sox10^Dom - 0.33 cM - Pdgfb - 0.11 cM - D15Mit2.