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Phenotype Images associated with this Allele
Nomenclature
Symbol: Tgdsem1(IMPC)Mbp
Name: TDP-glucose 4,6-dehydratase; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI ID: MGI:6430646
Synonyms: Tgds-
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)Mbp embryos have abnormal head shape, abnormal hearts accompanied by cardiac or pericardial edema, abnormal yolk sac morphology, and branchial arch defects and incomplete turning at E9.5. By E10.5, embryos are grossly abnormal.Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)MbpC57BL/6NCrl-Tgdsem1(IMPC)Mbp/Mmucd
Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)Mbp (-/-) placentas at E10.5 show an abnormal chorioallantoic interface (reduction in allantoic mesoderm) and multiple labyrinth zone defects. The labyrinth trophoblast layer is reduced and chorioallantoic branching is nearly absent.Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)MbpC57BL/6NCrl-Tgdsem1(IMPC)Mbp/Mmucd
E8.5 Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)Mbp (Tgds-/-) embryos have all 3 germ layers that appear appropriately patterned.Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)MbpC57BL/6NCrl-Tgdsem1(IMPC)Mbp/Mmucd
E9.5 Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)Mbp (Tgds -/- ) embryo has normal germ layer patterning but an abnormally large heart that is inappropriately looped.Tgdsem1(IMPC)Mbp/Tgdsem1(IMPC)MbpC57BL/6NCrl-Tgdsem1(IMPC)Mbp/Mmucd
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
MGI 6.24 		The Jackson Laboratory