Phenotype Image Detail

Image

Caption

Placental phenotype of Tgds^em1(IMPC)Mbp/Tgds^em1(IMPC)Mbp (Tgds-/-) embryos. At E9.5, Tgds-/- placentas are properly developed and comparable to controls. While Tpbpa staining appears more intense in the displayed KO placenta compared to the control littermate, it is not consistent with all KO and control placentas examined. At E10.5, Tgds-/- placentas exhibit an abnormal chorioallantoic interface (reduction in allantoic mesoderm) and multiple labyrinth zone defects compared to controls. In KO placentas, the Tfeb+ labyrinth trophoblast layer is reduced. Chorioallantoic branching is nearly absent as Gcm1 expression is sparse and remains at the chorioallantoic interface.

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598

Associated Alleles

Symbol	Name
Tgds^em1(IMPC)Mbp	TDP-glucose 4,6-dehydratase; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis

Associated Genotypes

Allelic Composition	Genetic Background
Tgds^em1(IMPC)Mbp/Tgds^em1(IMPC)Mbp	C57BL/6NCrl-Tgds^em1(IMPC)Mbp/Mmucd