Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Traf7^em1(IMPC)Tcp
Name:	TNF receptor-associated factor 7; endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI ID:	MGI:6388361
Synonyms:	Traf7^-

Images for
Allele

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Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Traf7^em1(IMPC)Tcp/Traf7^em1(IMPC)Tcp (-/-) embryos show developmental delay. Almost all E10.5 embryos have abnormal head shape and cardiac tissue, some with enlarged hearts and pericardial edema, abnormal branchial arch development, and abnormal blood deposition. Yolk sacs appear pale.	Traf7^em1(IMPC)Tcp/Traf7^em1(IMPC)Tcp	C57BL/6NCrl-Traf7^em1(IMPC)Tcp/TcpMmucd
	Traf7^em1(IMPC)Tcp/Traf7^em1(IMPC)Tcp (-/-) placentas exhibit multiple labyrinth zone defects. Thickness of the labyrinth layer is reduced and chorioallantoic branching is nearly absent.	Traf7^em1(IMPC)Tcp/Traf7^em1(IMPC)Tcp	C57BL/6NCrl-Traf7^em1(IMPC)Tcp/TcpMmucd
	E9.5 AlleleSymbol(MGI:6388361\|0)/Traf7^em1(IMPC)Tcp (Traf7-/-) embryos display appropriate germ layer formation. Embryos are mainly normal, displaying normal heart and liver development.	Traf7^em1(IMPC)Tcp/Traf7^em1(IMPC)Tcp	C57BL/6NCrl-Traf7^em1(IMPC)Tcp/TcpMmucd
	AlleleSymbol(MGI:6388361\|0)/Traf7^em1(IMPC)Tcp (-/-) embryos display appropriate germ layer formation at E10.5, however embryos are delayed and a reduction in cellular density, most easily seen in head sections, is seen.	Traf7^em1(IMPC)Tcp/Traf7^em1(IMPC)Tcp	C57BL/6NCrl-Traf7^em1(IMPC)Tcp/TcpMmucd

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