Phenotype Image Detail

Image

Caption

Placental phenotype in Traf7^em1(IMPC)Tcp/Traf7^em1(IMPC)Tcp (Traf7-/-) embryos. At E9.5, Traf7-/- placentas are properly developed and comparable to controls. At E10.5, Traf7-/- placentas exhibit multiple labyrinth zone defects compared to control littermates. In KO placentas, the Tfeb+ labyrinth trophoblast layer is reduced in thickness but displays elevated Tfeb signal intensity, suggesting an increased density of Tfeb+ cells. Chorioallantoic branching is nearly absent, as Gcm1 expression is sparse and remains at the chorioallantoic interface.

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598

Associated Alleles

Symbol	Name
Traf7^em1(IMPC)Tcp	TNF receptor-associated factor 7; endonuclease-mediated mutation 1, The Centre for Phenogenomics

Associated Genotypes

Allelic Composition	Genetic Background
Traf7^em1(IMPC)Tcp/Traf7^em1(IMPC)Tcp	C57BL/6NCrl-Traf7^em1(IMPC)Tcp/TcpMmucd