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Phenotype Images associated with this Allele
Nomenclature
Symbol: Kash5tm1b(KOMP)Wtsi
Name: KASH domain containing 5; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:5700363
Synonyms: Kash5-null
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Small testes and narrow seminiferous tubules devloid of elongated spermatids and mature sperm in Kash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsi malesKash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsiinvolves: C57BL/6J * C57BL/6N
Homologue pairing is defective in Kash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsi spermatocytesKash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsiinvolves: C57BL/6J * C57BL/6N
DNA double strand breaks persist in Kash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsi testesKash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsiinvolves: C57BL/6J * C57BL/6N
Reduction in the association of telomeres with SUN1 in Kash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsi spermatocytesKash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsiinvolves: C57BL/6J * C57BL/6N
Cytoplasmic dynein is not recruited to telomere attachement sites at the nuclear envelope of Kash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsi spermatocytesKash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsiinvolves: C57BL/6J * C57BL/6N
Gametogenesis defect in Kash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsi femalesKash5tm1b(KOMP)Wtsi/Kash5tm1b(KOMP)Wtsiinvolves: C57BL/6J * C57BL/6N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory