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Phenotype Images associated with this Allele
Nomenclature
Symbol: Mapk7b2b2346Clo
Name: mitogen-activated protein kinase 7; Bench to Bassinet Program (B2B/CVDC), mutation 2346 Cecilia Lo
MGI ID: MGI:5554435
Synonyms: Smiley
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2346-004-2 (E16.5) exhibits parallel outflow tracts, hypoplastic transverse arch, and thin ventricles which is diagnosed as DORV and ventricular non-compaction by EFIC imagingMapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
Color flow spectral Doppler imaging in the sagittal view of mutant 2346-004-2 (E16.5) shows the two great arteries predominantly originating from the RV, which suggests DORV. This was confirmed by EFIC imaging
Click thumbnail to play movie.		Mapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
EFIC SummaryMapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
Serial 2D EFIC image stack in the coronal plane of 2346-004-2 (E16.5) reveals DORV, subaortic VSD, hypoplastic transverse aorta, and ventricular non-compaction
Click thumbnail to play movie.		Mapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
Mutant 2346-004-2 (E16.5) shows hypoplastic kidneys with hydronephrosisMapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
Mutant 2346-004-1 (E16.5) was found dead and showed developmentally delay with parallel outflow tracts, and thin ventricles, subsequently shown to be DORV and ventricular non-compaction by EFIC imagingMapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
EFIC SummaryMapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
Serial 2D EFIC image stack in the coronal plane of 2346-004-1 (E16.5) shows developmental delay, DORV, AVSD, and ventricular non-compaction
Click thumbnail to play movie.		Mapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
Mutant 2346-004-3 (E16.5) shows a narrow ductus arteriosusMapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
EFIC SummaryMapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
Serial 2D EFIC image stack in the coronal plane of 2346-004-3 (E16.5) shows pmVSD, mVSD, narrow DA
Click thumbnail to play movie.		Mapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
Mutant 2346-004-3 (E16.5) has cystic kidneys, hydronephrosis, and hydroureterMapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
The kidneys of 2346-004-3 have hydronephrosisMapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
Kidneys of 2346-004-3 have cystic tubules and glomeruli. The left kidney shows a hydroureter; the right kidney shows hydronephrosisMapk7b2b2346Clo/Mapk7b2b2346CloC57BL/6J-Mapk7b2b2346Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory