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Phenotype Images associated with this Allele
Nomenclature
Symbol: Dnm2b2b2159Clo
Name: dynamin 2; Bench to Bassinet Program (B2B/CVDC) mutation 2159, Cecilia Lo
MGI ID: MGI:5491244
Synonyms: Boo
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2159-003-2 (E16.5) shows parallel outflow tracts which is diagnosed as DORV by EFIC imagingDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
EFIC SummaryDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Serial 2D EFIC image stack in the coronal plane of 2159-003-2 (E16.5) shows DORV, subaortic VSD, and incomplete vascular ring
Click thumbnail to play movie.		Dnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
3D reconstruction of 2159-003-2 showing heart in chest cavity
Click thumbnail to play movie.		Dnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Mutant 2159-003-2 (E16.5) exhibits an encephaloceleDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Mutant 2159-003-2 (E16.5) exhibits a cleft palateDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Kidneys from mutant 2159-003-2 have the appearance of cystsDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Mutant 2159-003-2 exhibits kidneys with tubular and glomerular cystsDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Mutant 2159-003-2 exhibits renal tubular and glomerular cystsDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Mutant 2159-003-3 (E16.5) has hydrocephalusDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Mutant 2159-003-3 (E16.5) exhibits a cleft palateDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Mutant 2159-003-3 (E16.5) has abnormal placement of the outflow which is diagnosed as overriding aorta by EFIC imagingDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
EFIC SummaryDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Serial 2D EFIC image stack in the coronal plane of 2159-003-3 (E16.5) exhibits overriding aorta and pmVSD
Click thumbnail to play movie.		Dnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Mutant 2159-003-6 (E16.5) has cleft palateDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Mutant 2159-003-2 (E16.5) shows malaligned great arteries, and narrowing of the ductus arteriosusDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Mutant 1259-003-4 exhibits hydroneprhosis with hydrometerDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
EFIC SummaryDnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Serial 2D EFIC image stack in the coronal plane of 2159-003-4 (E16.5) shows overriding aorta, pmVSD, and LV hypertrophy
Click thumbnail to play movie.		Dnm2b2b2159Clo/Dnm2b2b2159CloC57BL/6J-Dnm2b2b2159Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory