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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b1200Clo
Name: Mutant line 1200; Bench to Bassinet Program (B2B/CVDC), mutation 1200 Cecilia Lo
MGI ID: MGI:5437101
Synonyms: Bruiser
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1200-003-NA shows dextroversion {S,D,S} with vascular ringb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Mutant 1200-003-NA shows malaligned sternovertebraeb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Mutant 1200-003-NA shows dextrocardia with normal liver and stomach situsb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
EFIC Summaryb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Serial 2D EFIC image stack in the coronal plane of 1200-003-NA reveals dextroversion (rightward rotated heart), left-side juxtaposition of atrial appendage {S,D,N}, AVSD, small RV, vascular ring, right aortic arch, isolated left subclavian artery
Click thumbnail to play movie.		b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Serial 2D EFIC image stack in the coronal plane of 1200-003-NA reveals dextroversion, {S,D,S}, hypoplastic RV, perimembranous VSD, ASD(II), RAA, left PDA, and vascular ring
Click thumbnail to play movie.		b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Serial 2D EFIC image stack in the coronal plane of 1200-003-NA reveals Dextroversion (rightward rotated heart), left-side juxtaposition of atrial appendage, {S,D,N}, AVSD, small RV, vascular ring, right aortic arch, isolated left subclavian artery
Click thumbnail to play movie.		b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Serial 2D EFIC image stack in the coronal plane of 1200-003-NA reveals dextroversion, {S,D,S}, hypoplastic RV, perimembranous VSD, ASD(II), RAA, left PDA, and vascular ring
Click thumbnail to play movie.		b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Kidney tubule show short cilia.b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Kidney tubules show cilia with varying length, some with knobby tips.b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Mutant 1200-007-2 (E17) shows dextrocardia with abnormal arch and dilated ductus arteriosusb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Mutant 1200-007-2 (E17) shows abnormal arch with dilated ductus arteriosusb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Mutant 1200-007-2 (E17) shows bilateral duplex kidney, cystic kidney disease, hydronephrosis, and hydroureterb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
EFIC Summaryb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
2D serial EFIC image stacks in the coronal plane of 1200-007-2 reveals perimembranous and 2 muscular VSDs, spongie ventricular wall, dysplastic semilunar valve, hypoplastic transverse aortic arch.
Click thumbnail to play movie.		b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Hypoplastic transverse archb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Mutant 1200-007-2 shows bilateral duplex kidneys and hydroureterb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Mutant 1200-007-2 shows bilateral duplex or multiplex kidneysb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Immunofluorescence of ureteric budb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Mutant 1200-004-NC exhibit malaligned great arteries.b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
EFIC Summaryb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
2D EFIC image stack of 1200-004-NC in coronal view reveals overriding aorta, perimembranous and muscular VSDs
Click thumbnail to play movie.		b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
Mutant 1200-004-NC exhibits multiplex kidney with severe hydronephrosis.b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
Slit2b2b1200.1Clo/Slit2b2b1200.1CloC57BL/6J-Slit2b2b1200.1Clo
EFIC Summaryb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
Serial 2D EFIC image stack in the coronal plane of 1200-007-4 reveals ventricular hypertrophy
Click thumbnail to play movie.		b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
2D serial MRI image stack in the coronal plane of 1200-007-4 (E17.0) reveals ventricular hypertrophy and bilateral duplicated kidney
Click thumbnail to play movie.		b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
EFIC Summaryb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
Serial 2D EFIC image stack of 1200-007-3 (ED17) in coronal plane view reveals spongy ventricles
Click thumbnail to play movie.		b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
Mutant 1200-007-3 exhibits multiplex kidneysb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
Mutant 1200-007-3 exhibits multiplex kidneysb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
Mutant 1200-007-3 shows bilateral duplex or multiplex kidneys with cysts, and is also likely to have hydronephrosis and hydroureterb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
2D micro-MRI image stack of 1200-004-ND in coronal plane reveals bilateral duplex/multiplex kidney
Click thumbnail to play movie.		b2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
Mutant 1200-004-ND exhibits multiplex kidney with severe hydronephrosisb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
Mutant 1200-004-ND exhibits multiplex kidney with severe hydronephrosisb2b1200Clo/b2b1200CloC57BL/6J-b2b1200Clo
b2b1200.2Clo/b2b1200.2CloC57BL/6J-b2b1200.2Clo
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory