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Phenotype Images associated with this Allele
Nomenclature
Symbol: Trp53tm1Tyj
Name: transformation related protein 53; targeted mutation 1, Tyler Jacks
MGI ID: MGI:1857263
Synonyms: p53-, p53-, p53delta, p53KO, p53null, Trp53-, Trp53KO
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Increased apoptosis in the developing central nervous system of Rps7Zma/Rps7+ embryos which is reduced in Rps7Zma/Rps7+ Trp53tm1Tyj/Trp53+ embryosRps7Zma/Rps7+involves: BALB/c * C3H/HeH * C57BL/6J
Rps7Zma/Rps7+
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * BALB/c * C3H/HeH * C57BL/6J
Embryonic developmental delay in Rps7Zma/Rps7+ mice is suppressed by Trp53 deficiencyRps7Zma/Rps7+involves: BALB/c * C3H/HeH * C57BL/6J
Rps7Zma/Rps7+
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * BALB/c * C3H/HeH * C57BL/6J
Tg(Ly6e-MALT1)#Isg/0 Trp53tm1Tyj/Trp53tm1Tyj mice develop activated B-cell diffuse large-cell lymphomaTrp53tm1Tyj/Trp53tm1Tyj
Tg(Ly6e-MALT1)#Isg/0
involves: 129S2/SvPas * C57BL/6 * CBA
Characterization of lmphomas in Tg(Ly6e-MALT1)#Isg/0 Trp53tm1Tyj/Trp53tm1Tyj miceTrp53tm1Tyj/Trp53tm1Tyj
Tg(Ly6e-MALT1)#Isg/0
involves: 129S2/SvPas * C57BL/6 * CBA
Persistent hyperplastic primary vitreous (PHPV) in Cdkn2atm1Cjs/Cdkn2atm1Cjs mice is p53 independentCdkn2atm1Cjs/Cdkn2atm1Cjsinvolves: 129X1/SvJ * C57BL/6
Cdkn2atm1Cjs/Cdkn2atm1Cjs
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory