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| Caption | Gcn1em1(IMPC)J/Gcn1em1(IMPC)J (Gcn1-/-) embryos are always the smallest in their litters beginning at E7.5. By E8.5 Gcn1-/- are delayed compared with control littermates. At E9.5 all Gcn1-/- embryos remain unturned or display incomplete turning. When analyzable, the yolk sac is not appropriately vascularized. Mutants always have an abnormal head shape and this is often accompanied by improper cranial neural tube closure. By E10.5 more than half of the embryos are dying/undergoing resorption. The other half display turning defects, have severe cardiac defects and an open cranial neural tube. A single mutant has turned and appears like a normal E10.5 embryo. | ||||
| Copyright | This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/30/2025 MGI 6.24 |
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