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| Caption | Inflammation in aortic roots obtained from atheroprone mice with (Apoetm1Unc/Apoetm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1tm1Paw/Nck1tm1Paw Nck2tm3Paw/Nck2tm3Paw) and without (Apoetm1Unc/Apoetm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1tm1Paw/Nck1tm1Paw) endothelial-specific deletion of NCK2. Animals were fed a HFD for 8 or 16 weeks to assess atherosclerotic lesion initiation and progression, respectively. (A/C) Representative confocal images of aortic roots showing immunofluorescence staining of the cell adhesion (VCAM-1) and leukocyte infiltration (Mac-2) markers in males (A) and females (C). The dotted yellow and white lines contour the aortic root section and the neointima, respectively. The scale bars represent 50 um unless otherwise indicated. (B/D) Box plots displaying quantification of total Mac-2 or VCAM (left panels) and neointimal Mac-2 or VCAM-1 (right panels) in males (B) and females (D). Total Mac-2 and VCAM-1 were calculated as Mac-2 or VCAM-1 area in entire root/root area. Neointimal Mac-2 and VCAM-1 were calculated as Mac-2 or VCAM-1 area in the neointima/area of neointima. Dots represent individual animals and the number of animals per group is indicated in parentheses. Statistical significance was determined by Wilcoxon Rank Sum Test with Bonferroni correction. *p < 0.05. | ||||||||||
| Copyright | This image is from the Laboratory of Dr. Gonzalo M Rivera at Texas A&M University and is displayed with the permission of the author. J:327349 | ||||||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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