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| Caption | Reduced expression of Lhx2 hampers hair follicle morphogenesis. (A,B) Alkaline phosphatase (AP) staining of skin sections of E16.5 embryos (A) and E18.5 embryos (B) revealing the number of hair follicles (HFs) in skin of control embryos (upper panels) compared to skin in Lhx2tm1Lcar/Lhx2tm1Lcar (Lhx2Neo/Neo) embryos (lower panels). (C) Estimation of HF density based on the AP staining of skin of E16.5 embryos (left) and E18.5 embryos (right) comparing control embryos to mutant embryos. Data are presented as average +/- SD. *p < 0.005. **p < 0.0001 (Student's t-test). (D) Skin sections of E16.5 embryos were analysed by in situ hybridization for expression of the indicated genes encoding mediators of signaling pathways involved in HF morphogenesis (arrow heads), and analysed by immunohistochemistry for expression of E-cad in epidermis comparing control embryos (upper panels) to mutant embryos (lower panels). Scale bars, 100 um. | ||||
| Copyright | This image is from Tornqvist G, PLoS Genet 2010;6(4):e1000904, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:159209 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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