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| Caption | Increased apoptosis occurs in the developing central nervous system (CNS) of Rps7Zma/Rps7+ (Z/+) mutant embryos; however, this apoptosis is reduced in Rps7Zma/Rps7+ Trp53tm1Tyj/Trp53+ (Z/+;p53/+) embryos. (A-C) Increased apoptosis was observed in E11.5 Rps7Zma/Rps7+ coronal sections through the neocortex compared to wild-type (+/+) and Rps7Zma/Rps7+ Trp53tm1Tyj/Trp53+, as measured by cleaved caspase-3 (CC3) staining shown in green. (D-F) Apoptosis was also relatively increased in neural tube cross-sections of Rps7Zma/Rps7+ embryos at E11.5 (E). (G-I) Cellular disorganization was apparent in mitotic, phosphohistone H3-positive (PH3+) cells surrounding the lumen of the neural tube in E11.5 Rps7Zma/Rps7+ embryos (H). | ||||||
| Copyright | This image is from Watkins-Chow DE, PLoS Genet 2013 Jan;9(1):e1003094, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195156 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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