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| Caption | (D) H&E staining of the sections from bone marrow located within the femur and spleen of aged wild-type (WT) and Sh2b3tm1Paw/Sh2b3tm1Paw (Lnk-/-) mice are shown. Mutant spleens exhibit marked extramedullary hematopoiesis, with disruption of the normal splenic architecture, due to infiltration of mature myeloid cells into the red pulp along with increased numbers of megakaryocytes. Bone marrow of aged mutants shows increased numbers of granulocytic and monocytic cells. Original magnification, x40 (D, center panel); x400 (D, left and right panels). | ||||
| Copyright | This image is from Bersenev A, J Clin Invest 2010 Jun 1;120(6):2058-69 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:161643 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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