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| Caption | Embryonic abnormalities and craniofacial dysmorphology in Gtf2itm1Vcam/Gtf2itm1Vcam (deltaex2/deltaex2) mutant mice. A. H&E staining, Ki67 labeling and TUNEL assay. Sections from normal (top) and abnormal (bottom) E7.5 embryos derived from crosses between heterozygous females and homozygous males. Abnormal embryos lacking detectable embryonic layers by H&E staining are likely to correspond to nonviable homozygous embryos. Normal embryos displayed high levels of Ki67-positive cells while they are not detectable in abnormal embryos. No differences were observed in the TUNEL staining. B. Morphologic abnormalities in mutant mice at 8 weeks of age. (Left) The histogram shows the relative average distance from the tip of the nose to the proximal occipital suture (n = 10 per genotype). Pair wise comparisons revealed statistically significant differences between genotypes (Tukey test; P = 0.003 and P = 0.048 for homozygous and heterozygous relative to wild-type, respectively). (Right) representative photograph of the dissected cranial structure per genotype is shown. A shorter snout could be clearly appreciated in the homozygous mice. wild-type, open; heterozygous, grey; and homozygous, black squares. | ||||
| Copyright | This image is from Lucena J, BMC Med Genet 2010;11():61, an open-access article, licensee BioMed Central Ltd. J:204278 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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