About   Help   FAQ
Phenotype Image Detail
Image
Caption Spongiform degeneration of the neonatal PikfyveGt(AT0926)Wtsi/PikfyveGt(AT0926)Wtsi (PikfyveBeta-geo/Beta-geo) mouse heart. Saggital sections of neonatal wild-type (WT) and homozygous mutant mice stained with H&E. The atria (At), ventricles (V), and lung (L) of WT littermates exhibit normal morphology. At higher magnification, atrial and ventricular myocytes strongly stain with H&E. There is no apparent vacuolation. Homozygous mice have reduced H&E staining of atrial myocytes consistent with reduced myofibrillar content. In the homozygous mutants, both atria and ventricles have vacuoles (arrows), with a high level of vacuolation in the atria. Smaller vacuoles (arrowheads) give the myocytes (identified by heavily stained myofibrils (white arrow)) a foamy appearance.
Copyright This image is from Zolov SN, Proc Natl Acad Sci U S A 2012 Oct 23;109(43):17472-7. Copyright 2012 National Academy of Sciences, U.S.A. J:190368
Associated
Alleles
Symbol Name
PikfyveGt(AT0926)Wtsi phosphoinositide kinase, FYVE type zinc finger containing; gene trap AT0926, Wellcome Trust Sanger Institute
Associated
Genotypes
Allelic Composition Genetic Background
PikfyveGt(AT0926)Wtsi/PikfyveGt(AT0926)Wtsi involves: 129P2/OlaHsd * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/07/2024
MGI 6.23
The Jackson Laboratory