About   Help   FAQ
Phenotype Image Detail
Image
Caption Tg(Ly6e-MALT1)#Isg/0 Trp53tm1Tyj/Trp53tm1Tyj (Sca1-MALT1,p53-/-) mice develop activated B-cell diffuse large-cell lymphoma (ABC-DLBCL). (B) Macroscopic aspect of the intestine and spleen in double mice vs. wild-type (WT) and Trp53tm1Tyj/Trp53tm1Tyj (p53-/-) age-matched mice. (C) Representative hematoxylin-eosin (HE) staining and IHC analysis for CD20, Foxp1, Mum1, Gcet1, CD10, and Bcl6 in double mutant mice. Appropriate positive and negative control tissues for each antibody were used.
Copyright This image is from Vicente-Duenas C, Proc Natl Acad Sci U S A 2012 Jun 26;109(26):10534-9. Copyright 2012 National Academy of Sciences, U.S.A. J:185590
Associated
Alleles
Symbol Name
Tg(Ly6e-MALT1)#Isg transgene insertion, Isidro Sanchez-Garcia
Trp53tm1Tyj transformation related protein 53; targeted mutation 1, Tyler Jacks
Associated
Genotypes
Allelic Composition Genetic Background
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Ly6e-MALT1)#Isg/0
involves: 129S2/SvPas * C57BL/6 * CBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory