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| Caption | A, electron microscopy images of flexor digitorum brevis (FDB) muscles from 3-month-old Tg(SOD1*G93A)1Gur/0 (G93A) and wild-type (WT) mice. In the WT, mitochondria (arrows) aligned within the sarcomeric I band and had uniform sizes (panel 2). In contrast, the mutant muscle (panel 1) had enlarged mitochondria with vacuoles (panels 3-5), invading the sarcomeric A band. B, live muscle fibers probed simultaneously with Mito-Tracker Deep Red (panels 1 and 3) and tetramethylrhodamine ethyl ester (TMRE) (panels 2 and 4). A segment with depolarized mitochondria is identified in the mutant fiber (panel 2, bracket). The corresponding segment in the MitoTracker Deep Red image shows fuzzy staining with loss of contrast, due to morphological alterations of mitochondria (panel 1). Both mitochondrial probes stain the WT fiber equally and homogeneously (panels 3 and 4). C, overlays of TMRE (green) and alpha-bungarotoxin (alpha-BTX) images (red) of dually stained mutant FDB fibers. Areas of mitochondrial defects had variable size, but they always faced the neuromuscular junction (NMJ). | ||||
| Copyright | This image is from Zhou J, J Biol Chem 2010 Jan 1;285(1):705-12 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:158298 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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