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| Caption | Histopathologic and ultrastructural changes in Slc26a9tm1Sole/Slc26a9tm1Sole gastric mucosa. (A) H&E staining shows gastric glands in Slc26a9tm1Sole/Slc26a9tm1Sole (Slc26a9-/-) mouse as dilated (D indicates dilated gastric gland) and containing lucent contents, which did not appear eosinophilic or basophilic, and small amounts of cellular debris (center and right) vs. wild-type (Scl26a9+/+, left) mice. Parietal cell numbers were decreased in mutant mice (blue arrows). Zymogen cells were significantly reduced in mutant stomach (right, white arrow). Mucous cells in mutant stomach contained a significant amount of hyaline granules (right, dark blue). (B) Electron microscopy shows parietal cell ultrastructure. There was a distinct and striking absence of tubulovesicles (TV) in parietal cells in mutant (right) vs. wild-type stomach (left). In place of tubulovesicles, parietal cells in mutant mice had abundant amounts of round vesicles (RV), which could be a premature or undeveloped form of tubulovesicle. Insets show a low-magnification image of part of a parietal cell, including nucleus (N), mitochondria, and areas of secretory membranes [canaliculi (black arrows) and tubulovesicles in the wild-type, and canaliculi (black arrows) and round vesicles in the mutant]. The higher-magnification images of secretory membranes of the wild-type and mutant are labeled similarly. The flattened tubulovesicles typical of the wild-type parietal cell were replaced by round vesicles in the mutant. The white circle in each of the main figures surrounds a cross-section of a microvillus. In the wild-type the actin filaments in the mircovillus are largely found peripherally and in close proximity to the plasma membrane, but in the mutant the actin filaments are centrally located in a core. (Scale bars: A, 100 um for light micrographs; B, 1 um for electon micrograph). | ||||
| Copyright | This image is from Xu J, Proc Natl Acad Sci U S A 2008 Nov 18;105(46):17955-60. Copyright 2008 National Academy of Sciences, U.S.A. J:142516 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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