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| Caption | Apoptosis and distribution of hepato- and erythropoiesis in livers of Juntm1Wag/Juntm1Wag mouse fetuses. Liver sections of E13.0 wild-type (+/+, A and C) and Juntm1Wag/Juntm1Wag (-/-, B and D-F) littermates. The hematoxylin and eosin stained sections (A and B) show numerous cells with condensed nuclei, typical for apoptotic cells (arrowheads in B) in mutant livers. These nuclei contain fragmented DNA, as demonstrated by TUNEL staining (C and D, arrowheads in D). The cell types that undergo apoptosis were characterized using rabbit antibodies to keratins 8/18 (E) and the monoclonal rat antibody TER119 (F), respectively. Bound antibodies were detected by the APAAP procedure and sections were counterstained with H&E. In E hepatoblasts with fragmented nuclei (filled arrowheads) and hepatoblasts with intact nuclei are visible. Some of the hepatoblasts contain apoptotic bodies (open arrowhead) engulfed by phagocytosis. In F TER119-positive erythroid cells containing fragmented nuclei are shown (arrowheads). Distribution of hepatopoiesis and erythropoiesis in livers of E12.5 wild-type (G) and mutant littermates (H). Liver sections were double-labeled with antibodies to hepatoblasts and erythroid cells using rabbit antibodies to keratins 8 and 18 (green) and the monoclonal rat antibody TER119 (red), respectively. Bars, 20 um. | ||||
| Copyright | This image is from Eferl R, J Cell Biol 1999 May 31;145(5):1049-61, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:55508 | ||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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