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| Caption | A: Morphology of E7.5 wild-type (+/+) and Prkar1atm1Gsm/Prkar1atm1Gsm (-/-) embryos. Mutant embryos are smaller than wild-type littermates but have a well formed A-P axis, including head-folds, node and allantois. B: Morphology of E8.5 wild-type and mutant embryos. Mutant embryos show severe growth retardation and developmental delay resembling presomite head-fold stage embryos. The cardiogenic plate is present but no heart tube had formed. C: Morphology of E9.5 wild-type and mutant embryos. E9.5 mutant embryos are severely growth-retarded, have failed to form a contractile heart tube, and have not initiated the turning process. D: Comparison of an E9.5 mutant embryo with wild-type embryos from several stages of development. Mutant embryos at E9.5 resemble E8.0 wild-type embryos. Although mutants are approximately the same size as E8.0 wild-type embryos, mutants differ in that they have more somites, an allantois that is thickened at the base, a more radical entry of the foregut, and bilateral cardiocytes that have failed to fuse ventrally to form the heart. Scale bars: A-D, 500 um. Abbreviations: al, allantois; cp, cardiogenic plate; fg, foregut; hp, head process; ht, heart; nd, node; tr, trunk; ys, yolk sac. | ||||
| Copyright | This image is from Amieux PS, J Biol Chem 2002 Jul 26;277(30):27294-304 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:78010 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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