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Phenotype Image Detail
Image
Caption A: Lenses dissected from Gja8tm1Paul/Gja8tm1Paul mice at P14 were smaller than those of control littermates (B) and exhibited an irregular and diffuse nuclear opacity (A, arrow) not present in control lenses. By 6 months of age (C), mutant lenses had a fine particulate precipitate confined to the nucleus (C, arrow), characteristic of zonular pulverulent cataracts. In addition, a sharply defined line in the inner cortical region of the lens was present (arrowhead), the nature of which is not clear. D: 6 month old control lenses had no light scattering opacities. Bar, 1 mm.
Copyright This image is from White TW, J Cell Biol 1998 Nov 2;143(3):815-25, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:50894
Associated
Alleles
Symbol Name
Gja8tm1Paul gap junction protein, alpha 8; targeted mutation 1, David L Paul
Associated
Genotypes
Allelic Composition Genetic Background
Gja8tm1Paul/Gja8tm1Paul involves: 129S4/SvJae * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory