Gja8^tm1Paul
Targeted Allele Detail

Summary

• Symbol: Gja8^tm1Paul
• Name: gap junction protein, alpha 8; targeted mutation 1, David L Paul
• MGI ID: MGI:2137411
• Synonyms: alpha8(-), Cx-50^-
• Gene: Gja8 Location: Chr3:96820882-96833336 bp, - strand
• Alliance: Gja8^tm1Paul page

Nuclear cataracts in Gja8^tm1Paul/Gja8^tm1Paul mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50894
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The entire coding region was replaced with a neomycin resistance cassette. (J:50894)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja8 Mutation: 33 strains or lines available

References

• Original: J:50894 White TW, et al., Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts. J Cell Biol. 1998 Nov 2;143(3):815-25
• All: 10 reference(s)