Phenotype Image Detail

Image

Caption

Smooth muscle coverage of aorta in embryos. A: E13.5 S1pr2^tm1Rlp/S1pr2⁺ S1pr3^tm1Rlp/S1pr3^tm1Rlp. B: S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp double null. C: S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/? embryos were sectioned transversely at the thoracic level and immunostained with anti-smooth muscle alpha-actin. S1pr2^tm1Rlp/S1pr2⁺ S1pr3^tm1Rlp/S1pr3^tm1Rlp and S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp aortae were covered normally by vascular smooth muscle cells (brackets in panels A and B). However, smooth muscle cell coverage was discontinuous around the aorta in the S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/? embryo (arrows in panel C). Scale bars, 50um.

This image is from Kono M, J Biol Chem 2004 Jul 9;279(28):29367-73 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:106055

Associated
Alleles

Symbol	Name
S1pr1^tm2Rlp	sphingosine-1-phosphate receptor 1; targeted mutation 2, Richard L Proia
S1pr2^tm1Rlp	sphingosine-1-phosphate receptor 2; targeted mutation 1, Richard L Proia
S1pr3^tm1Rlp	sphingosine-1-phosphate receptor 3; targeted mutation 1, Richard L Proia
Tg(Tek-cre)1Ywa	transgene insertion 1, Masashi Yanagisawa

Associated
Genotypes

Allelic Composition	Genetic Background
S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/?	involves: 129S6/SvEvTac * C57BL/6 * SJL
S1pr3^tm1Rlp/S1pr3^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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