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| Caption | Histological analysis of cardiac cells in Pparatm1Gonz/Pparatm1Gonz and wild-type mice. A: Light microscopy. The myocardium of the wild-type mouse (a and d) at the age of 32 weeks seemed to be normal. The myocardium of the Pparatm1Gonz/Pparatm1Gonz mouse at the age of 16 weeks (b and e) showed a little focal fibrosis. In the mutant mouse at 32 weeks (c and f), diffuse dense fibrosis was evident in the myocardium. Fibrosis (arrows) is stained blue with Azan-Mallory staining (f). HE, hematoxylin and eosin stain. Original magnification, x100. B: Electron microscopy. Upper panels show mitochondria in the myocardial cells. The wild-type mouse at the age of 32 weeks (A). The mutant mouse at the age of 16 weeks (B) and 32 weeks (C). Cristae increased in number and density in the mutant mouse. Lower panels show caveolae in the cardiac capillary endothelial cells. The wild-type mouse at the age of 32 weeks (D). The caveolae in mutant mouse at the age of 16 weeks (E) and 32 weeks (F) were more numerous than those in the wild-type mouse (D). Bar = 1um. | ||||
| Copyright | This image is from Watanabe K, J Biol Chem 2000 Jul 21;275(29):22293-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:63801 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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