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Targeted Allele Detail
Symbol: Pparatm1Gonz
Name: peroxisome proliferator activated receptor alpha; targeted mutation 1, Frank J Gonzalez
MGI ID: MGI:1857774
Synonyms: mPPARalpha-, PPAR-alpha-, PPARalpha-, PPARalpha-null, PparatniJGonz
Gene: Ppara  Location: Chr15:85619184-85687020 bp, + strand  Genetic Position: Chr15, 40.42 cM
Alliance: Pparatm1Gonz page
Accumulation of intracellular lipid in the liver of fasted Pparatm1Gonz/Pparatm1Gonz mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:25516
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette replaced 83 bp of the coding sequence in exon 8. Northern blot analysis did not detect a transcript of wild-type size on RNA derived from liver of homozygous mice. An larger abnormal transcript was detected. Western blot analysis did not detect PPARA protein in extracts derived from livers of homozygous mice. (J:25516, J:91859)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 132 assay results
In Structures Affected by this Mutation: 13 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Pparatm1Gonz
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Ppara Mutation:  32 strains or lines available
Original:  J:25516 Lee SS, et al., Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol. 1995 Jun;15(6):3012-22
All:  378 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory