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| Caption | A: Light photomicrographs from an Ush2atm1Tili/Ush2atm1Tili mouse retina at the age of 20 months and an age matched wild type (WT) mouse are shown. The photoreceptor cell layer in the mutant was much thinner than that of the wild type mouse. B: Representative electroretinogram (ERG) tracings from a mutant at 20 months of age and an age-matched wild type control are shown (Left). ERG data from a cohort of mutant and control mice are summarized (Right). Both a- and b-wave amplitudes from the mutant (n = 8) were reduced significantly compared with the control (n = 9) (P<0.001). OS, outer segment; IS, inner segment; ONL, outer nuclear layer; INL, inner nuclear layer; GC, retinal ganglion cells. C: Immunofluorescence for cone opsins and glial fibrillary acidic protein (GFAP) in mutant and wild type mice. Cone opsin antibodies (mixed blue and green cone opsin antibodies) stained well organized cone outer segments in the wild type retina but highlighted cell bodies and little outer segments in the mutant (at 20 months; left). GFAP was up-regulated in the mutant (at 2 months; right). Immunostaining signals are shown in orange. Cell nuclei are counterstained blue with Hoechst dye 33342. | ||||
| Copyright | This image is from Liu X, Proc Natl Acad Sci U S A 2007 Mar 13;104(11):4413-8. Copyright 2007 National Academy of Sciences, U.S.A. J:118927 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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