Ush2a^tm1Tili
Targeted Allele Detail

Summary

• Symbol: Ush2a^tm1Tili
• Name: usherin; targeted mutation 1, Tiansen Li
• MGI ID: MGI:3702040
• Synonyms: Ush2a^-
• Gene: Ush2a Location: Chr1:187995035-188697694 bp, + strand Genetic Position: Chr1, 92.29 cM
• Alliance: Ush2a^tm1Tili page

Retinal degeneration in the Ush2a^tm1Tili/Ush2a^tm1Tili mouse

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118927
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Most of exon 5 was replaced by a neomycin resistance cassette. (J:118927)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ush2a Mutation: 290 strains or lines available

References

• Original: J:118927 Liu X, et al., Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4413-8
• All: 10 reference(s)