| Image |
|
||||||
| Caption | Comparison of spinal cord pathology in 130-day-old Tg(SOD1)2Gur/0 (Panels A-E) and Tg(SOD1-G93A)1Gur/0 (Panels F-J) mice and in the human Amyotrophic lateral sclerosis (ALS) spinal cord (Panels K-O). Staining is done with the following: rabbit anti-NFL polyclonal antiserum (NFL, Panels A,F,K), alpha-internexin mAb (INT, Panels B,G,L), rabbit antiperipherin polyclonal antiserum (PPH, Panels C,H,M), ubiquitin mAb (UBI, Panels D,I,N), and GFAP mAb (Panels E,J,O). Note that pathology in Tg(SOD1-G93A)1Gur/0 mice resembles that in human ALS. The alpha-internexin mAb stains the spheroids in human ALS less strongly than in the transgenic mice (arrow in L), and one spheroid is not stained (arrowhead in L). The Tg(SOD1)2Gur/0 mice also develop spheroids similar to those seen in Tg(SOD1-G93A)1Gur/0 mice and human ALS. Neurofilament and alpha-internexin colocalize in the same spheroids (arrowheads in F and G). However, ubiquitin and GFAP antibodies barely stain the anterior horns of the Tg(SOD1)2Gur/0 mice but strongly stain the Tg(SOD1-G93A)1Gur/0 mice and the human ALS. Some of the reactive astrocytes in the Tg(SOD1-G93A)1Gur/0 mice are extremely hypertrophic and contain inclusion-like GFAP immunoreactive material (Panel E, insert). All sections were counterstained with hematoxylin. | ||||||
| Copyright | This image is from Tu PH, Proc Natl Acad Sci U S A 1996 Apr 2;93(7):3155-60. Copyright 1996 National Academy of Sciences, U.S.A. J:76718 | ||||||
|
Associated Alleles |
|
||||||
|
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools