| Image |
|
||||||
| Caption | Generation of the Abcb1atm1Kane (mdr1aflox) and Abcb1atm1.1Kane (mdr1aFLUC) alleles. (a) The map shows murine Abcb1a (mdr1a) exons 1 to 3 (boxes), respective introns (thin line), and upstream genomic sequences (thin line). Also shown are the targeting DNA construct, the targeted allele Abcb1atm1Kane (mdr1aflox), and the Cre-recombined knock-in allele Abcb1atm1.1Kane (mdr1aFLUC). Exons in white or a hatched pattern are nontranslated; exons in gray are translated, with the initiating ATG indicated. Black bars (A and B) indicate positions of Southern hybridization probes. Key restriction sites are also indicated. Neo: neo gene under the control of the PGK promoter, used as the positive selection marker. Luc: fLUC cDNA fused in-frame with the noncoding part (hatched) of Abcb1a exon 2. TK: HSV-thymidine kinase gene, used as the negative selection marker. Arrowheads: loxP sites, targets for Cre recombinase. | ||||||
| Copyright | This image is from Gu L, Proc Natl Acad Sci U S A 2009 Mar 31;106(13):5394-9. Copyright 2009 National Academy of Sciences, U.S.A. J:147139 | ||||||
|
Associated Alleles |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools