Abcb1atm1Kane
Targeted Allele Detail
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Symbol: |
Abcb1atm1Kane |
Name: |
ATP-binding cassette, sub-family B member 1A; targeted mutation 1, Susan E Kane |
MGI ID: |
MGI:3842696 |
Synonyms: |
Mdr1aflox |
Gene: |
Abcb1a Location: Chr5:8710077-8798575 bp, + strand Genetic Position: Chr5, 3.43 cM
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Alliance: |
Abcb1atm1Kane page
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Germline Transmission: |
Earliest citation of germline transmission:
J:147139
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Parent Cell Line: |
2A (ES Cell)
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Strain of Origin: |
129S1/SvImJ
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: A luciferase cDNA fused in-frame with the noncoding part of exon 2 gene was preceded by a floxed neomycin expression cassette that contained a synthetic polyadenylation sequence to stop transcription. This construct was inserted downstream of exon 2 with an additional loxP site inserted upstream of the exon. Upon cre recombinase mediated excision of exon 2 and the neo cassette, luciferase will be expressed under the control of endogenous locus.
(J:147139)
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Generation of the Abcb1atm1Kane and Abcb1atm1.1Kane alleles |
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Abcb1a Mutation: |
93 strains or lines available
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Original: |
J:147139 Gu L, et al., A new model for studying tissue-specific mdr1a gene expression in vivo by live imaging. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5394-9 |
All: |
1 reference(s) |
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