Molecular Image Detail

Image

Caption

Generation of the Ankle1^{tm1(KOMP)Wtsi}, Ankle1^{tm1.1(KOMP)Wtsi} and Ankle1^{tm1.2(KOMP)Wtsi} alleles. (A) Schematic drawing of the Ankle1 wild-type locus with exons 1 to 9, the knock-out allele carrying the complete deletion cassette, Ankle1^{tm1(KOMP)Wtsi} (Ankle1-) consisting of FRT recombination sites (semi circle), splice acceptors site (En2 SA), Internal Ribosome Entry Site (IRES), LacZ gene (LacZ), polyadenylation site (pA), loxP recombination site (triangle), Beta-actin promoter (Beta-act.-p.) and aminoglycoside phosphotransferase gene (neo) and the knock-out allele after CRE-recombination, Ankle1^{tm1.1(KOMP)Wtsi} (Ankle1^deltaneo) carrying the reporter gene cassette only and the knock-out allele after FLP-mediated recombination, Ankle1^{tm1.2(KOMP)Wtsi} (Ankle1^delta).

This image is from Braun J, PLoS One 2016;11(3):e0152278, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:235782

Associated
Alleles

Symbol	Name
Ankle1^{tm1.1(KOMP)Wtsi}	ankyrin repeat and LEM domain containing 1; targeted mutation 1.1, Wellcome Trust Sanger Institute
Ankle1^{tm1.2(KOMP)Wtsi}	ankyrin repeat and LEM domain containing 1; targeted mutation 1.2, Wellcome Trust Sanger Institute
Ankle1^{tm1(KOMP)Wtsi}	ankyrin repeat and LEM domain containing 1; targeted mutation 1, Wellcome Trust Sanger Institute
Ankle1^{tm1(KOMP)Wtsi}	ankyrin repeat and LEM domain containing 1; targeted mutation 1, Wellcome Trust Sanger Institute

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