Ankle1^{tm1.1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Ankle1^{tm1.1(KOMP)Wtsi}
• Name: ankyrin repeat and LEM domain containing 1; targeted mutation 1.1, Wellcome Trust Sanger Institute
• MGI ID: MGI:5827621
• Synonyms: Ankle1^deltaneo
• Gene: Ankle1 Location: Chr8:71858654-71862548 bp, + strand Genetic Position: Chr8, 34.43 cM
• Alliance: Ankle1^{tm1.1(KOMP)Wtsi} page
• IMPC: Ankle1 gene page

Mutation origin

• Mutant Cell Line: EPD0323_2_B12
• Germline Transmission: Earliest citation of germline transmission: J:235782
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P Mutation details: Cre-mediated excision of the parental Ankle1^tm1(KOMP)Wtsi allele resulted in the removal of the neomycin selection cassette and critical exons (exons 2 to 9) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:235782)

Generation of the Ankle1^tm1(KOMP)Wtsi, Ankle1^tm1.1(KOMP)Wtsi and Ankle1^tm1.2(KOMP)Wtsi alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ankle1 Mutation: 27 strains or lines available

References

• Original: J:235782 Braun J, et al., The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis. PLoS One. 2016;11(3):e0152278
• All: 1 reference(s)