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| Caption | Generation of the Ppp2r5dtm1Vjan allele. (A) Schematic overview of the wild-type allele (top), targeting construct (middle) and targeted allele (bottom). In the targeting vector, a neomycin cassette of 1.2 kb replaces 3.9 kb of wild-type sequence. The Southern blot probes (5' probe and neo probe) and the sizes of the BclI/BamHI restriction enzyme fragments detected with those probes are indicated. The arrows indicate the approximate positions of the PCR primers initially used for ES cell genotyping. Because exons 1 and 2 and part of exon 3 are not targeted, a polypeptide consisting of the 50 N-terminal amino acids of the Ppp2r5d protein might still be produced. | ||||
| Copyright | This image is from Louis JV, Proc Natl Acad Sci U S A 2011 Apr 26;108(17):6957-62. Copyright 2011 National Academy of Sciences, U.S.A. J:171339 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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