Ppp2r5d^tm1Vjan
Targeted Allele Detail

Summary

• Symbol: Ppp2r5d^tm1Vjan
• Name: protein phosphatase 2, regulatory subunit B', delta; targeted mutation 1, Veerle Janssens
• MGI ID: MGI:4950873
• Synonyms: PR61/B'delta^-
• Gene: Ppp2r5d Location: Chr17:46993917-47015952 bp, - strand Genetic Position: Chr17, 22.9 cM, cytoband C
• Alliance: Ppp2r5d^tm1Vjan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171339
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Sequence spanning most of exon 3 through exon 14 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver, heart, and brain extracts. (J:171339)

Generation of the Ppp2r5d^tm1Vjan allele

Tumor Data

List all tumor models in MMHCdb carrying Ppp2r5d^tm1Vjan

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2r5d Mutation: 34 strains or lines available

References

• Original: J:171339 Louis JV, et al., Mice lacking phosphatase PP2A subunit PR61/B'{delta} (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3{beta}. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6957-62
• All: 4 reference(s)