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| Caption | Generation of the Gria2tm1.1Bvis (flox) allele. (A1) The Gria2 flox-neo allele. Shown are exons 10, 11 and 12, the loxP sites (open arrows), neomycin resistance (NeoR) gene, targeting construct (indicated by solid line), and 5', 3' and INT probes used for Southern blotting (gray boxes). Exon 11 encodes membrane domains 1 and 2 of the Gria2 protein, including the critical site of RNA editing (Q/R site). B = BamHI, S = SpeI. (A2) The Gria2tm1.1Bvis allele. Cre transfection of ES cells containing the flox-neo allele results in excision of the NeoR gene in some ES cells. (A3) The knock-out allele. Cre-recombination can be used to excise the exon 11-containing fragment and NeoR gene entirely from the GluR2 gene, leaving a single loxP and BamHI site in its place. | ||||
| Copyright | This image is from Wiltgen BJ, PLoS One 2010;5(9):, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223717 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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