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| Caption | Construction of the Krastm1.1Hbji (Loxp-Stop-Loxp-ER-K-rasG12D) allele. The Stop codon was flanked with two LoxP sites; the Neo cassette is flanked with two FRT sites; Positive selection cassette contains the gene for a viral Neo cassette and negative selection cassette contains the gene for a viral thymidine kinase (TK). The original mice were then crossed with beta actin-Flpe to delete the Neo cassette. Thymidine kinase (TK); BamH I (B); Kpn I (K); Not I (N); Xba I (Xb); Sph I (S); ER, estrogen receptor cDNA; *, GGT to GAT mutation at codon 12. | ||||
| Copyright | This image is from Wang Z, PLoS One 2012;7(5):e37308, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:220921 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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