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| Caption | Generation of the Eps8l2tm1Wma allele. (A) Scheme depicting the genomic organization of Eps8l2 (upper line) and the targeting vector (lower line). The two exons coding for the SH3 domain (red), which were replaced by the neomycin cassette (gray), are indicated. The 3' probe used for Southern blot analysis (green) is located just outside of the targeted region. The EcoRI sites in the WT allele and in the targeting vector are indicated (EcoRI). The position of primers a, b, c (gray) and d, e, f (blue) used to screen for targeting and correct insertion at the 5' end, respectively, are also indicated (not to scale). Primer a is located 5' of exon XVI, primers b, e, and f are located in the neomycin cassette, and primers c and d are located in the Eps8l2 gene outside of the region used for the construction of targeting vector. | ||||
| Copyright | This image is fromFurness DN, Proc Natl Acad Sci U S A 2013 Aug 20;110(34):13898-903. Copyright2013 National Academy of Sciences, U.S.A. J:200669 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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