Eps8l2^tm1Wma
Targeted Allele Detail

Summary

• Symbol: Eps8l2^tm1Wma
• Name: EPS8-like 2; targeted mutation 1, Walter Marcotti
• MGI ID: MGI:5544327
• Gene: Eps8l2 Location: Chr7:140918824-140942933 bp, + strand Genetic Position: Chr7, 86.66 cM
• Alliance: Eps8l2^tm1Wma page

Hair bundle abnormalities in hair cells from adult Eps8l2^tm1Wma/Eps8l2^tm1Wma mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200669
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 16 and 17 were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in lungs from homozygous mice. (J:200669)

Generation of the Eps8l2^tm1Wma allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eps8l2 Mutation: 37 strains or lines available

References

• Original: J:200669 Furness DN, et al., Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13898-903
• All: 1 reference(s)